胆汁酸関連論文

杉山 雄一

• Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 272: G16-22, 1997.
• Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T and Sugiyama Y. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Mol. Pharmacol. 53: 1068-1075, 1998.
• Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J. Biol. Chem. 273: 1684-1688. 1998.
• Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA and Sugiyama Y. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett. 433: 149-152, 1998.
• Hirohashi T, Suzuki H and Sugiyama Y. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J. Biol. Chem. 274: 15181-15185, 1999.
• Hirohashi T, Suzuki H, Takikawa H and Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J. Biol. Chem. 275:.2905-2910, 2000.
• Ogawa K, Suzuki H, Hirohashi T, Ishikawa T, Meier PJ, Hirose K, Akizawa T, Yoshioka M and Sugiyama Y. Characterization of inducible nature of MRP3 in rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G438-446, 2000.
• Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H and Sugiyama Y. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim. Biophys. Acta 1511: 7-16, 2001.
• Akita H, Suzuki H and Sugiyama Y. Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver. Pharm. Res. 18: 1119-1125, 2001.
• Ito K, Suzuki H and Sugiyama Y. Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G1034-1043, 2001.
• Ito K, Suzuki H and Sugiyama Y. Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2. Mol. Pharmacol. 59: 1077-1085, 2001.
• Akita H, Suzuki H, Hirohashi T, Takikawa H and Sugiyama Y. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm. Res. 19: 34-41, 2002.
• Akita H, Suzuki H and Sugiyama Y. Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3. Biochem. Biophys. Res. Commun. 299: 681-687, 2002.
• Horikawa M, Kato Y, Tyson CA and Sugiyama Y. Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab. Pharmacokinet. 18: 16-22, 2003.
• Hayashi H, Takada T, Suzuki H, Akita H and Sugiyama Y. Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. Hepatology. 41: 916-924, 2005.
• Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF and Sugiyama Y. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: A comparison of human BSEP with rat Bsep. Biochim. Biophys. Acta. 1738: 54-62, 2005.
• Hirano M, Maeda K, Hayashi H, Kusuhara H and Sugiyama Y. Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J. Pharmacol. Exp. Ther. 314: 876-882, 2005.
• Hirouchi M, Suzuki H and Sugiyama Y. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Pharm. Res. 22: 661-666, 2005.
• Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF and Sugiyama Y. Vectorial transport of bile salts across MDCK cells expressing both rat Na⁺-taurocholate cotransporting polypeptide and rat bile salt export pump. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G159-167, 2005.
• Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF and Sugiyama Y. Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC- PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G550-556, 2006.
• Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF and Sugiyama Y. Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs. Drug Metab. Dispos. 34: 1575-1581, 2006.
• Sakamoto S, Suzuki H, Kusuhara H and Sugiyama Y. Efflux mechanism of taurocholate across the rat intestinal basolateral membrane. Mol. Pharm. 3: 275-281, 2006.
• Hayashi H and Sugiyama Y. 4-Phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. Hepatology. 45: 1506-1516, 2007.
• Sakamoto S, Kusuhara H, Miyata K, Shimaoka H, Kanazu T, Matsuo Y, Nomura K, Okamura N, Hara S, Horie K, Baba T and Sugiyama Y. Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-na phthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action. J. Pharmacol. Exp. Ther. 322: 610-618, 2007.
• Hayashi H and Sugiyama Y. Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11). Mol. Pharmacol. 75: 143-150, 2009.
• Hayashi H, Inamura K, Aida K, Naoi S, Horikawa R, Nagasaka H, Takatani T, Fukushima T, Hattori A, Yabuki T, Horii I and Sugiyama Y. AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. Hepatology. 55: 1889-1900, 2012.
• Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H and Sugiyama Y. 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration. J. Hepatol. 56: 1136-1144, 2012.
• Aida K, Hayashi H, Inamura K, Mizuno T and Sugiyama Y. Differential roles of ubiquitination in the degradation mechanism of cell surface-resident BSEP and MRP2. Mol. Pharmacol. 85: 482-491, 2014.
• Hayashi H and Sugiyama Y. Bile salt export pump (BSEP/ABCB11): trafficking and sorting disturbances. Curr. Mol. Pharmacol. 6: 95-103, 2013.
• Aida K, Hayashi H, Inamura K, Mizuno T and Sugiyama Y. Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2. Mol. Pharmacol. 85: 482-491, 2014.
• Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y and Kusuhara H. 6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects. Drug Metab. Dispos. 42: 685-694, 2014.
• Naoi S, Hayashi H, Inoue T, Tanikawa K, Igarashi K, Nagasaka H, Kage M, Takikawa H, Sugiyama Y, Inui A, Nagai T and Kusuhara H. Improved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2. J. Pediatr. 164: 1219-1227.e3, 2014.